This work builds on the synergetic triad Soft Computing — Internet — Multi Agent Systems in developing technologies for remote diagnosis, prediction and ubiquitous healthcare. Our approach extends the holonic enterprise paradigm to the medical domain. A medical holarchy is a system of collaborative medical entities (patients, physicians, medical devices, etc.) that work together to provide a needed medical service for the benefit of the patient. Representing holons as software agents enables the development of e-health environments as web-centric medical holarchies with a wide area of application in telemedicine. Our approach exploits the triad’s synergy twofold. On one side we use soft computing to enhance to power of the Internet by a fuzzy-evolutionary approach enabling emergence of virtual communities in Cyberspace. On the other side we use the Internet to empower soft computing both as enabler for the powerful integration of several soft computing strategies into a unified diagnosis and prediction methodology and as enhancer of learning neuro-fuzzy diagnostic rules and knowledge base refinement through a remote database creation and exploitation mechanism. A case study in glaucoma progression monitoring illustrates the benefits of our approach.