Conflict is inherent to all types of interpersonal relationships. The interdependence that characterizes romantic relationships is related to the way that men and women perceive intimate partner conflict. The emotion of guilt also plays an important role in the perception of conflict. In the present research we study how, in a conflictive situation, dependency in the relationship is related to guilt in men and women. A total of 116 young Spaniards (half men and half women) were exposed to a plausible conflict situation with their partners. Fifty-eight were undergraduate Psychology students who came to the laboratory with their partners (also mainly college students). The perceived seriousness of the conflict was manipulated, and the study explored how this perception affected the emotion of guilt. We also analyzed the effect of dependency on the intensity of experienced guilt. Results showed that women with high dependency felt guiltier than women with low dependency in high-conflict situations.