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Sommario L’insufficienza ovarica primaria (POI) colpisce l’1% delle donne <40 anni. Le forme più gravi si presentano con mancato sviluppo puberale, mentre le forme con esordio post-puberale sono caratterizzate da amenorrea secondaria associata a un anticipato esaurimento follicolare. Come nel caso della menopausa fisiologica, la POI si presenta con le manifestazioni tipiche del climaterio....
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