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During the development of Type 1 diabetes, inflammatory cytokines are known to induce the expression of inducible nitric oxide synthase (iNOS) in pancreatic islets, and subsequent production of nitric oxide (NO) contributes to β cell destruction. Glucagon-like peptide-1 (GLP-1) has been shown to reduce cytokine-in-duced apoptosis of β cells. In this study, we investigated whether GLP-1 affects cytokine-in-duced...
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