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Purpose of Review Liquid biopsy analyses based on circulating cell-free nucleic acids, circulating tumor cells or other diseased cells from organs, and exosomes or other microvesicles in blood offer new means for non-invasive diagnostic applications. The main goal of this review is to explain the importance of preserving whole blood specimens after blood draw for use as liquid biopsies, and to summarize...
Purpose of Review Extracellular vesicles (EVs) are lipid membrane vesicles released by many types of cells in both health and disease. EVs can be found in most body fluids, carrying a plethora of biomolecules, including proteins, RNA, and DNA, that reflect the biomolecular composition of the tissue of origin. Parenchymal and stromal cells actively release EVs in the extracellular milieu and in circulation,...
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