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S-adenosyl-l-homocysteine hydrolase (SAHH) is a ubiquitous enzyme that plays a significant role in methylation-based processes by maintaining the intracellular balance between S-adenosylhomocysteine and S-adenosylmethionine. In the past years, some analogs and derivatives of aristeromycin have been reported as a potential inhibitor of Plasmodium falciparum’s SAHH (PfSAHH), but no effective therapy...
Cytidylate kinase (CMK) plays a central role in the phosphorylation of ATP to nucleoside diphosphates in the purine and pyrimidine pathway in Mycobacterium tuberculosis (MTB). The enzyme is specific to bacteria, fungi, and plants and it shares the same pathway with a DNA-directed RNA polymerase subunit beta, the known target of rifampicin (RIF). Therefore, it serves as an attractive alternative target...
Autism is a developmental disorder characterized by abnormal communication-verbal behaviors. This disorder affects the brain normal growth and development associated with social interactions and communication skills. The real cause of the disease is still unknown; however, some studies are working on identifying the disease cause. One research approach is to study the social networks of mass communication...
Protein crystallization screening helps determine factors (e.g., salts, pH of buffers, ionic strengths, temperature, and type of precipitants) that are favorable for the formation of a large protein crystal suitable for X-ray crystallography. While existing commercial screens may not generate crystalline outcomes for difficult proteins, their outcomes could be used for recommending novel screens....
We consider the following problem: given an undirected (mixed) network and a set of ordered source–target pairs, or cause–effect pairs, direct all edges so as to maximize the number of pairs that admit a directed source–target path. This is called the maximum graph orientation problem, and has applications in understanding interactions in protein–protein interaction networks. Since this problem is...
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