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Rheumatoid arthritis (RA) is a chronic autoimmune disease that causes inflammation of the joints and may cause inflammation of other tissues in the body. It is mainly caused by combination of factors including abnormal autoimmune response, genetic susceptibility and some environmental or biological triggers. A number of pathways have been shown to be affected wherein numerous molecules are known to...
Network-based approaches to human disease have diverse biological and clinical applications. A more appropriate interpretation of biological interconnectivity with disease progression could possibly lead to identification of disease pathways and disease genes. This, in turn, helps in accurate prediction of biomarkers and targets for drug development. This study is a large-scale system-level network...
A system can be defined as an organized, interconnected structure consisting of interrelated and interdependent elements (e.g., components, factors, members, parts). These parts and processes are connected by structural and/or behavioral relationships and continually influence one another directly or indirectly to maintain a balance essential for the existence of the system, and for achieving its...
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