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Two-dimensional (2D), Three-dimensional (3D) quantitative structure–activity relationship (QSAR) and Pharmacophore studies of angiotensin II AT1 receptor antagonists substituted imidazolones derivatives have been carried out. Statistically significant best 2D-QSAR and k-nearest neighbor-based 3D-QSAR model were generated on q2 = 0.7118; 0.7159 with pred_r2 = 0.8313, 0.7377, respectively,...
A series of 47 indole-3-carboxamide derivatives with their renin inhibitors were subjected to QSAR to derive a correlation between biological activity as a dependent variable and various descriptors as independent variables. The best 2D-QSAR model having cross-validated squared correlation coefficient q2 = 0.7847 with external predictive of pred_r2 = 0.8193. Based on k-nearest neighbor method the...
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