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Plasma membranes are essential components of living cells, and phospholipids are major components of cellular membranes. Here, we used liquid chromatography/mass spectrometry to investigate changes in the membrane phospholipid content that occur in association with aging. Our results indicate that the levels of a particular species of phosphatidylcholine comprised of stearic acid and arachidonic acid...
Human fibroblasts, which have a finite lifespan in cultures, have been widely used as a model system for cellular aging, and frequently used as one model of human aging. But whether cellular aging contributes to organismal aging has been controversial. To reinvestigate this question, we cultured human fibroblasts from the skin of one individual volunteer collected at different ages. Over a period...
The relationship between cellular aging and aging of entire organisms has been studied extensively. The findings are confusing, however, and no clear relationships have been demonstrated. The conflicting data may be due to individual differences among the donors of the studied cells. It is crucial to identify the changes in cellular properties that are the result of the aging process. Here, we used...
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