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RNA editing is a mechanism for generating molecular diversity by altering the genetic code at the level of RNA. The 5-HT2C receptor is the only G protein-coupled receptor known to be edited. It has been reported that the non-edited 5-HT2C receptor stimulates secretion of the APP metabolite APP ectodomain (APPs). However, it remains unknown whether RNA-edited 5-HT2C receptors can also affect APPs secretion...
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