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The central role in the pathogenesis of anthrax is played by the two classical anthrax toxins. Three factors that are secreted by the bacterium combine to form two bipartite toxins. Edema toxin, consisting of the protective antigen (PA) and the edema factor (EF), causes the edema associated with anthrax infection. Lethal toxin (LeTx), composed of PA and the lethal factor (LF), is believed to be responsible...
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