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Ethylbenzene (EB) is an important industrial chemical that has recently been classified as a possible human carcinogen. We investigated the effects of administration of EB equivalent to 10% and 50% of LD50 dose on rats and analyzed their liver proteomes at 72 h after dosing. Approximately 1,100 protein spots that were detected by 2-dimensional gel electrophoresis showed reproducible abundance. 11...
Benz[a]anthracene (B[a]A) is one of the most ubiquitous polycyclic aromatic hydrocarbons and environmental pollutants. Mass spectrometrybased proteomics was used to characterize changes in the liver proteome in response to B[a]A exposure. Nine hepatic protein spots were identified that exhibited B[a]A-induced significant expression changes. Of these, six were up-regulated and the rest were downregulated...
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