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Background Resistance to mammary tumorigenesis in Copenhagen rats isassociated with loss of early preneoplastic lesions known as intraductalproliferations. The cause of this disappearance, however, is unknown. Results There were no differences in the numbers of lesions in mammarywhole-mounts prepared from Copenhagen or Wistar-Furth rats at 20 or 30 daysafter N-methyl-N-nitrosourea treatment, but...
A proportion of breast carcinomas develop as a result of a genetic predispostion to the disease. Prior to cloning of the BRCA1 and BRCA2 genes a limited number of studies were carried out to identify specific histopathological characteristics of hereditary breast cancer. These studies are the subject of this review. The main finding was the association of the (atypical) medullary type of breast cancer...
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