Journal of Negative Results in BioMedicine

Items from 1 to 15 out of 15 results

article

Erratum to: Do anti-amyloid beta protein antibody cross reactivities confound Alzheimer disease research?

Sally Hunter, Carol Brayne

Journal of Negative Results in BioMedicine > 2017 > 16 > 1 > 1-2

The online version of the original article can be found under doi: 10.1186/s12952-017-0066-3 .

article

Experimental silicosis does not aggravate collagen-induced arthritis in mice

Robby Engelmann, Brigitte Müller-Hilke

Journal of Negative Results in BioMedicine > 2017 > 16 > 1 > 1-5

Objectives To investigate the effect of chronic lung inflammation on the incidence and severity of collagen-induced arthritis in mice. Methods Chronic lung inflammation in the form of silicosis was induced via intranasal application of silica particles. Immunization with collagen Type II commenced one week later and mice were sacrificed six weeks after booster immunization. Thereafter, silicosis...

article

The diagnostic value of the bronchoalveolar lavage in interstitial lung diseases

Boubacar Efared, G. Ebang-Atsame, Sani Rabiou, Abdoulsalam S. Diarra, more

Journal of Negative Results in BioMedicine > 2017 > 16 > 1 > 1-6

Objective Bronchoalveolar lavage (BAL) is a diagnostic tool often used during the management of interstitial lung diseases (ILD). However, its diagnostic value in discrimination between entities comprising the very heterogenous group of ILD, is still a controversial issue. The objective of our study is to assess the diagnostic value of BAL in the management of ILD, by comparing the cytological findings...

article

Lack of association between polymorphism rs540782 and primary open angle glaucoma in Saudi patients

Altaf A. Kondkar, Nikhil B. Edward, Hatem Kalantan, Abdullah S. Al-Kharashi, more

Journal of Negative Results in BioMedicine > 2017 > 16 > 1 > 1-5

Background To investigate whether polymorphism rs540782 on chromsome 1, in close proximity to the Zona Pellucida Glycoprotein 4 (ZP4) gene, is a risk factor for primary open angle glaucoma (POAG). Method The study genotyped 92 unrelated POAG cases and 95 control subjects from Saudi Arabia using Taq-Man® assay. Results The genotype frequency distribution did not deviate significantly from the Hardy-Weinberg...

article

Facial cutaneo-mucosal venous malformations can develop independently of mutation of TEK gene but may be associated with excessive expression of Src and p-Src

Nabila Brahami, Selvakumar Subramaniam, Moudjahed Saleh Al-Ddafari, Cecile Elkaim, more

Journal of Negative Results in BioMedicine > 2017 > 16 > 1 > 1-8

We aimed to search for mutations in the germline and somatic DNA of the TEK gene and to analyze the expression level of Src and phospho-Src (p-Src) in tumor and healthy tissues from patients with facial cutaneo-mucosal venous malformations (VMCM). Eligible patients from twelve families and thirty healthy controls were recruited respectively at the Departments of Stomatology and Oral Surgery, and Transfusion...

article

Antimicrobial activity of HL-60 cells compared to primary blood-derived neutrophils against Staphylococcus aureus

Ragheda Yaseen, Stefanie Blodkamp, Petra Lüthje, Friederike Reuner, more

Journal of Negative Results in BioMedicine > 2017 > 16 > 1 > 1-7

Background The human leukemia cell line HL-60 is considered an alternative cell culture model to study neutrophil differentiation and migration. The aim of this study was to characterize the suitability of HL-60 cells differentiated to neutrophil-like cells (nHL-60) as substitute for blood-derived human neutrophils to investigate the interaction of neutrophils with Staphylococcus aureus. Methods...

article

Do anti-amyloid beta protein antibody cross reactivities confound Alzheimer disease research?

Sally Hunter, Carol Brayne

Journal of Negative Results in BioMedicine > 2017 > 16 > 1 > 1-8

Background Alzheimer disease (AD) research has focussed mainly on the amyloid beta protein (Aβ). However, many Aβ-and P3-type peptides derived from the amyloid precursor protein (APP) and peptides thought to derive from Aβ catabolism share sequence homology. Additionally, conformations can change dependent on aggregation state and solubility leading to significant uncertainty relating to interpretations...

article

Does the placebo effect modulate drug bioavailability? Randomized cross-over studies of three drugs

Muhammad M Hammami, Ahmed Yusuf, Faduma S. Shire, Rajaa Hussein, more

Journal of Negative Results in BioMedicine > 2017 > 16 > 1 > 1-12

Background Medication effect is the sum of its drug, placebo, and drug*placebo interaction effects. It is conceivable that the interaction effect involves modulating drug bioavailability; it was previously observed that being aware of caffeine ingestion may prolong caffeine plasma half-life. This study was set to evaluate such concept using different drugs. Methods Balanced single-dose, two-period,...

article

Absence of the dermatan sulfate chain of decorin does not affect mouse development

Pierre Moffatt, Yeqing Geng, Lisa Lamplugh, Antonio Nanci, more

Journal of Negative Results in BioMedicine > 2017 > 16 > 1 > 1-9

Background In vitro studies suggest that the multiple functions of decorin are related to both its core protein and its dermatan sulfate chain. To determine the contribution of the dermatan sulfate chain to the functional properties of decorin in vivo, a mutant mouse whose decorin lacked a dermatan sulfate chain was generated. Results Homozygous mice expressing only the decorin core protein developed...

article

The effects of phosphanegold(I) thiolates on the biological properties of Acanthamoeba castellanii belonging to the T4 genotype

Ruqaiyyah Siddiqui, Farhat Abjani, Chien Ing Yeo, Edward R. T. Tiekink, more

Journal of Negative Results in BioMedicine > 2017 > 16 > 1 > 1-9

Background Gold compounds have shown promise in the treatment of non-communicable diseases such as rheumatoid arthritis and cancer, and are considered of value as anti-microbial agents against Gram-negative and Gram-positive bacteria, and have anti-parasitic properties against Schistosoma mansoni, Trypanosoma brucei, Plasmodium falciparum, Leishmania infantinum, Giardia lamblia, and Entamoeba histolytica...

article

Polymorphism rs547984 on human chromosome 1q43 is not associated with primary open angle glaucoma in a Saudi cohort

Taif A. Azad, Nikhil B. Edward, Altaf A. Kondkar, Hatem Kalantan, more

Journal of Negative Results in BioMedicine > 2017 > 16 > 1 > 1-5

Background To investigate the association between polymorphism rs547984, located in close proximity to the Zona Pellucida Glycoprotein 4 (ZP4) gene on human chromosome 1q43 and primary open angle glaucoma (POAG). Method Polymorphism rs547984 was genotyped using Taq-Man® assay in 185 subjects comprising of 90 unrelated POAG cases and 95 controls of Saudi origin. Results Association analysis between...

article

Behavioral and neural adaptations in response to five weeks of balance training in older adults: a randomized controlled trial

Jan Ruffieux, Audrey Mouthon, Martin Keller, Michael Wälchli, more

Journal of Negative Results in BioMedicine > 2017 > 16 > 1 > 1-9

Background While the positive effect of balance training on age-related impairments in postural stability is well-documented, the neural correlates of such training adaptations in older adults remain poorly understood. This study therefore aimed to shed more light on neural adaptations in response to balance training in older adults. Methods Postural stability as well as spinal reflex and cortical...

article

In vitro aggregating β-lactamase-polyQ chimeras do not induce toxic effects in an in vivo Caenorhabditis elegans model

Roel Van Assche, Charline Borghgraef, Jonathan Vaneyck, Mireille Dumoulin, more

Journal of Negative Results in BioMedicine > 2017 > 16 > 1 > 1-14

Background A series of human diseases are caused by the misfolding and aggregation of specific proteins or peptides into amyloid fibrils; nine of these diseases, referred to as polyglutamine diseases, are associated with proteins carrying an expanded polyglutamine (polyQ) region. While the presence of this latter is thought to be the determinant factor for the development of polyQ diseases, the non-polyQ...

article

Work-focused cognitive behavioral intervention for psychological complaints in patients on sick leave due to work-related stress: Results from a randomized controlled trial

Vita Ligaya Dalgaard, Lars Peter Sønderbo Andersen, Johan Hviid Andersen, Morten Vejs Willert, more

Journal of Negative Results in BioMedicine > 2017 > 16 > 1 > 1-12

Background Work-related stress is a global problem with negative implications for individuals and society. The purpose of the current study was to evaluate a stress management intervention for patients on sick leave due to work-related stress complaints using a three-armed randomized controlled design. Methods Participants were patients referred from three municipalities to the regional Department...

article

Blink rate is associated with drug-induced parkinsonism in patients with severe mental illness, but does not meet requirements to serve as a clinical test: the Curacao extrapyramidal syndromes study XIII

Charlotte L. Mentzel, P. Roberto Bakker, Jim van Os, Marjan Drukker, more

Journal of Negative Results in BioMedicine > 2017 > 16 > 1 > 1-6

Background Drug-induced parkinsonism (DIP) has a high prevalence and is associated with poorer quality of life. To find a practical clinical tool to assess DIP in patients with severe mental illness (SMI), the association between blink rate and drug-induced parkinsonism (DIP) was assessed. Methods In a cohort of 204 SMI patients receiving care from the only mental health service of the previous...

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Keywords

POAG (2)
ZP4 (2)
ABSENTEEISM (1)
ACANTHAMOEBA (1)
AGING (1)
ALZHEIMER DISEASE (1)
AMYLOID BETA PROTEIN (1)
AMYLOID PRECURSOR PROTEIN (1)
ANTIBODY (1)
ANTIPSYCHOTIC (1)
BALANCE TRAINING (1)
BIOAVAILABILITY (1)
BLINK RATE (1)
BRONCHOALVEOLAR LAVAGE (1)
CAENORHABDITIS ELEGANS (1)
CARTILAGE (1)
CEPHALEXIN (1)
COGNITIVE BEHAVIORAL THERAPY (1)
COGNITIVE DIFFICULTIES (1)
COLLAGEN (1)
COLLAGEN-INDUCED ARTHRITIS (1)
CORNEA (1)
CROSS REACTIVITY (1)
CUTANEO-MUCOSAL VENOUS MALFORMATIONS (1)
CYTOLOGY (1)
CYTOTOXICITY ASSAYS (1)
DECORIN (1)
DERMATAN SULFATE (1)
DEVELOPMENT (1)
DIAGNOSTIC (1)
DIRECT SEQUENCING (1)
DRUG-INDUCED PARKINSONISM (1)
ENCYSTATION (1)
EXCYSTATION (1)
EXPERIMENTAL DESIGN (1)
GERMLINE AND SOMATIC DNA (1)
GOLD COMPOUNDS (1)
H-REFLEX (1)
IBUPROFEN (1)
IN VIVO PROTEIN AGGREGATION (1)
INTERSTITIAL LUNG DISEASES (1)
KNOCKIN MOUSE (1)
MENTAL HEALTH (1)
MIDDLE-EAST (1)
MODEL POLYGLUTAMINE PROTEINS (1)
MUCOSAL IMMUNITY (1)
MYELOPEROXIDASE (1)
NEUTROPHIL EXTRACELLULAR TRAPS (1)
NON-POLYQ REGIONS (1)
P-SRC (1)
PARACETAMOL (1)
PERCEIVED STRESS (1)
PHAGOCYTOSIS (1)
PHARMACOKINETIC PARAMETERS (1)
PLACEBO EFFECT (1)
PLASMA TERMINAL HALF-LIFE (1)
POLYQ (1)
POSTURAL CONTROL (1)
RANDOMIZED CONTROLLED TRIAL (1)
RS540782 (1)
RS547984 (1)
SAUDI (1)
SEVERE MENTAL ILLNESS (1)
SILICOSIS (1)
SKIN (1)
SLEEP (1)
SRC (1)
STAPHYLOCOCCUS AUREUS (1)
TEK GENE (1)
TENDON (1)
TRANSCRANIAL MAGNETIC STIMULATION (1)
WOUND HEALING (1)
ZYMOGRAPHY (1)
Β-LACTAMASE BLAP (1)
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