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Background Small conductance calcium-activated potassium channels (SK channels) play a critical role in action potential repolarization in cardiomyocytes. Recently, the potential anti-arrhythmic effect of metformin in diabetic patients has been recognized, yet the underlying mechanism remains elusive. Methods Diabetic Goto-Kakizaki (GK) rats were untreated or treated with metformin (300 mg/kg/day)...
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