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Long-term plasticity plays an important role in the functional construction of neuronal networks. While anatomical wiring provides essential hardware for brain function, activity-dependent plasticity works as an adjustable software interface allowing sensory induced modification of transmission efficacy at given synaptic connections. In contrast to the vast majority of excitatory synapses, at distinct...
During prolonged whole cell recording, the intracellular contents are progressively dialyzed with the pipette solution; this often leads to significant changes in synaptic efficacy. To overcome this problem, we developed an approach allowing reliable extracellular stimulation of perisomatic synapses formed by CCK+/CB1+ interneurons onto CA1 pyramidal cells. Functional identification of this input...
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