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Inhibition of DNA repair mechanism through alkylating agents in tumor cells is an important method for cancer treatment. Alkylation damage repair gene AlkB was first reported in E. coli. In human and other mammals eight distinguishing homologs of AlkB were detected and are known as hABH1 to hABH8. Crystal structures of hABH2 and hABH3 elucidated the role of human AlkB homologs involved in DNA and...
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