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Activation of P2X7 receptor (P2X7R) and pannexin have been implicated in membrane permeabilization associated with ischemic cell death and many other inflammatory processes. P2X7R has a unique property of forming large pore upon repeated or prolonged application of agonist like ATP or 2′, 3′-(4-benzoyl) benzoyl ATP. It has been proposed that pannexin 1 (panx1) hemichannel associates with P2X7R to...
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