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The crucial role of regulatory T (Treg) cells in self-tolerance and downregulating immune response has been clearly established. Numerous different Treg subsets have been identified that possess distinct phenotypes and functions in various disease models. Among these subsets, αβ-TCR+CD3+CD4−CD8− double-negative (DN) Treg cells have been shown to be able to inhibit a variety of immune responses in...
The clinical relevance of humoral allosensitization has gained a lot of attention in the last few years. An increasing number of studies have demonstrated adverse graft survival in patients who have either preformed or post-transplant-developed anti-HLA antibodies. The detection of HLA antibodies and the specificity analysis have evolved over time from primarily cell-based to solid-phase methods,...
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