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Friend virus (FV) is a murine retrovirus that causes acute disease leading to lethal erythroleukemia in most strains of mice. Strains of mice that mount strong and rapid immune responses can recover from acute infection, but nevertheless develop life-long chronic infections. The study of this infection has revealed the types of immune responses required for both recovery from the acute phase and the...
Almost all individuals diagnosed with glioblastoma multiforme (GBM) will die of their disease as no effective therapies exist. Clearly, novel approaches to this problem are needed. Unlike the adaptive αβ T cell-mediated immune response, which requires antigen processing and MHC-restricted peptide display by antigen-presenting cells, γδ T cells can broadly recognize and immediately respond to a variety...
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