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The intestinal epithelium serves as one of human's primary interfaces with the outside world. This interface is very heavily colonized with bacteria and yet permits absorption of life-sustaining nutrients while protecting the tissues below from microbial on slaught. Although the gut epithelium had been classically thought to achieve this function primarily by functioning as a passive, albeit highly...
There are many types of colitis models in animals that researchers use to elucidate the mechanism of action of human inflammatory bowel disease (IBD). These models are also used to test novel therapeutics and therapeutic treatment regimens. Here, we will review the characteristics of the mdr1a−/− model of spontaneous colitis that we believe make this model an important part of the IBD researcher's...
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