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Subsequent to suppression of LH (GnRH) pulse frequency by progesterone (P) and estradiol (E2), LH pulse frequency remains slow for 7 days after P withdrawal if mid-luteal E2 concentrations are maintained. This may reflect an ability of E2 to potentiate the suppressive effects of low P levels. We explored this notion in a similar experimental paradigm by administering a P-receptor antagonist (mifepristone)...
Mifepristone is a synthetic progesterone antagonist that is being used widely for the treatment of various conditions such as endometriosis, glaucoma, meningiomas, breast, ovarian and prostate cancer, as well as for research purposes, in the conditional induction of gene expression by using artificial plasmid-based systems. Here, we report that exposure of A549 human lung cancer cells to mifepristone...
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