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Familial hemiplegic migraine type 2, an autosomal dominant form of migraine with aura, has been associated with four distinct mutations in the α2-subunit of the Na+,K+-ATPase. We have introduced these mutations in the α2-subunit of the human Na+,K+-ATPase and the corresponding mutations in the Bufo marinus α1-subunit and studied these mutants by expression in Xenopus oocyte. Metabolic labeling studies...
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