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The molecular mechanisms of immunomodulatory effects of the major reproductive hormones (human chorionic gonadotropin, leptin, ghrelin, progesterone, estriol, estradiol) underlying the formation of maternal tolerance to semiallogeneic fetus in different trimesters of human pregnancy are reviewed. New data on the effect of hormonal ensembles and hormonal-cytokine combinations, which are most significant...
Glioblastoma multiforme (GBL) is the most frequent and aggressive tumor of the brain. Mean survival time of GBL patients is only 12–15 months, despite most intensive treatments. To fight this severe, still almost incurable disease, a great number of researches are recruited. Here we review the results of the GBL investigations published recently (from the end of 2013 to the first half of 2014) that...
The basal- and GTP[S]-stimulated activities of cGMP-specific phosphodiesterase were measured in totally bleached bovine retinal rod outer segments suspensions at high and low free calcium ions concentration (≈100 μM and <10 nM, respectively). The obtained results suggest that the activity of free phosphodiesterase in rod outer segment membranes and all following processes (transducin activation,...
Experimental curves of lateral pressure and Volta potential previously measured vs . area of dimyristoylphosphatidylserine (DMPS) monolayer (PA diagram) (Ermakov et al., 2010) are analyzed in the framework of the model introduced by Ruckenstein and Li (1996, 1998) for lipid clusters. The same curves are described by some empirical parameters as an alternative mechanistic approach...
Electrostatic effects in lysine and polylysine adsorption at lipid membrane surface were studied. Electrokinetic measurements demonstrated that lysine induces similar dose-dependent changes of zeta-potential in suspensions of liposomes made from cardiolipin (CL) and phosphatidylserine (PS). These changes correlate well with numerical description of diffuse part of electric double layer by Gouy-Chapman-Stern...
Effects of hydrolysable tannins on plasma membranes of Chara corallina giant cells and lipid bilayer membrane (BLM) were studied. Tannin inhibited chloride channels of alga cell membranes in a dose-dependent manner. Current jumps emerging in BLM in the presence of tannin suggest formation of ion channels, predominantly anion selective. The presence of cholesterol in BLM increased...
The features of synaptic organization of tonic motor units in vertebrates, which are widely represented in amphibians and reptiles but preserved only as muscular systems serving sensory organs in mammals, are reviewed. Based on the previous classical works, the comparative description of innervation and neurotransmitter secretion of tonic muscular systems is given. The data on synaptic organization...
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