Frontiers of Medicine

article

Emergency strategies and trends in the management of liver trauma

Hongchi Jiang, Jizhou Wang

Frontiers of Medicine > 2012 > 6 > 3 > 225-233

The liver is the most frequently injured organ during abdominal trauma. The management of hepatic trauma has undergone a paradigm shift over the past several decades, with mandatory operation giving way to nonoperative treatment. Better understanding of the mechanisms and grade of liver injury aids in the initial assessment and establishment of a management strategy. Hemodynamically unstable patients...

article

Perioperative management for parturients with pulmonary hypertension: experience with 30 consecutive cases

Lulu Ma, Wei Liu, Yuguang Huang

Frontiers of Medicine > 2012 > 6 > 3 > 307-310

Pregnancy with pulmonary hypertension is considered to be associated with increased maternal and neonatal mortality. We retrospectively reviewed all parturients with pulmonary hypertension who registered at our hospital between 1999 and December 2008. We collected information about patient characteristics, including maternal age, gravida and para, pulmonary hypertension category, New York Heart Association...

article

Early and marked up-regulation of TNF-α in acute respiratory distress syndrome after cardiopulmonary bypass

Tao Li, Nanfu Luo, Lei Du, Jin Liu, more

Frontiers of Medicine > 2012 > 6 > 3 > 296-301

Despite the technique of cardiopulmonary bypass (CPB) improved the development of modern cardiac surgery, many factors during CPB have been reported to induce acute respiratory distress syndrome (ARDS). The present study was to investigate which pro-inflammatory factors involved in the early phase of ARDS. Ten patients underwent valve replacement surgery with or without ARDS were enrolled for analysis...

article

EMLA® cream coated on endotracheal tube with or without epidural lidocaine reduces isoflurane requirement during general anesthesia

Hai Yu, Qinjun Chu, Jin Liu, Li Chen, more

Frontiers of Medicine > 2012 > 6 > 3 > 302-306

This study was designed to evaluate the effect of tracheal topical anesthesia using EMLA® Cream (EC) coated on the endotracheal tube (ETT) with or without epidural anesthesia (EA) on isoflurane requirement during general anesthesia (GA) and investigate whether EC coated on the ETT with EA was associated with the additive effect compared with the effect when each anesthetic was administered independently...

article

Orthopaedic management in the polytrauma patient

Jason J. Halvorson, Holly T. -P. Pilson, Eben A. Carroll, Zhongyu John Li

Frontiers of Medicine > 2012 > 6 > 3 > 234-242

The past century has seen many changes in the management of the polytraumatized orthopaedic patient. Early recommendations for non-operative treatment have evolved into early total care (ETC) and damage control orthopaedic (DCO) treatment principles. These principles force the treating orthopaedist to take into account multiple patient parameters including hypothermia, coagulopathy and volume status...

article

Obesity and overweight prevalence and its association with undiagnosed hypertension in Shanghai population, China: a cross-sectional population-based survey

Xinjian Li, Jiying Xu, Haihong Yao, Yanfei Guo, more

Frontiers of Medicine > 2012 > 6 > 3 > 322-328

The aim of this study was to determine the prevalence of overweight and obese subjects in the Shanghai population of China and its association with undiagnosed hypertension, by taking age, gender and place of residence (urban or suburban) into account. A cross-sectional population-based survey was conducted in 2007. The sample included 13 359 participants aged 15–69 years.Weight, height, and blood...

article

Emergent limited perioperative transesophageal echocardiography: should new guidelines exist for limited echocardiography training for anesthesiologists?

Yong G. Peng, Gregory M. Janelle

Frontiers of Medicine > 2012 > 6 > 3 > 332-337

Bedside limited echocardiography, or focused cardiac ultrasound, continues to gain popularity in many emergency rooms, intensive care units, and operating rooms as a rapid method of assessing unstable patients. Effective monitoring of cardiovascular function in conditions like cardiac arrest or near-arrest is the crucial step to guide successful resuscitative efforts. Transesophageal echocardiography...

article

Mechanisms and impacts of chromosomal translocations in cancers

Jing H. Wang

Frontiers of Medicine > 2012 > 6 > 3 > 263-274

Chromosomal aberrations have been associated with cancer development since their discovery more than a hundred years ago. Chromosomal translocations, a type of particular structural changes involving heterologous chromosomes, have made a critical impact on diagnosis, prognosis and treatment of cancers. For example, the discovery of translocation between chromosomes 9 and 22 and the subsequent success...

article

AML1-ETO driven acute leukemia: insights into pathogenesis and potential therapeutic approaches

Megan A. Hatlen, Lan Wang, Stephen D. Nimer

Frontiers of Medicine > 2012 > 6 > 3 > 248-262

The AML1-ETO fusion transcription factor is generated by the t(8;21) translocation, which is present in approximately 4%–12% of adult and 12%–30% of pediatric acute myeloid leukemia (AML) patients. Both human and mouse models of AML have demonstrated that AML1-ETO is insufficient for leukemogenesis in the absence of secondary events. In this review, we discuss the pathogenetic insights that have been...

article

Potential indicators predict progress after surgical resection of gastrointestinal stromal tumors

Qinggang Hu, Shanglong Liu, Jianwei Jiang, Chen Zhang, more

Frontiers of Medicine > 2012 > 6 > 3 > 317-321

In order to find out the potential indicators predicting prognosis of malignant gastrointestinal stromal tumors (GISTs) after surgical resection, we collected clinical records of 80 patients with malignant GISTs. Tumor location, size, mitotic index, necrosis were compared with the prognosis of malignant GISTs by Kaplan-Meier method and log-rank test. After a median follow-up of 844 days (52–2 145),...

article

Dual faces of SH2-containing protein-tyrosine phosphatase Shp2/PTPN11 in tumorigenesis

Shuangwei Li, Diane DiFang Hsu, Hongyang Wang, Gen-Sheng Feng

Frontiers of Medicine > 2012 > 6 > 3 > 275-279

PTPN11, which encodes tyrosine phosphatase Shp2, is a critical gene mediating cellular responses to hormones and cytokines. Against original prediction as tumor suppressor for tyrosine phosphatases, PTPN11 was first identified as a proto-oncogene because activating mutations of this gene are associated with leukemogenesis. However, most recent experimental data suggest PTPN11/Shp2 acting as a tumor...

article

The second short-term warm ischemia after vascular anastomosis did not affect early renal function recovery in renal transplantation: a case report

Tao Qiu, Jiangqiao Zhou, Xiuheng Liu, Minghuan Ge, more

Frontiers of Medicine > 2012 > 6 > 3 > 329-331

Ischemic postconditioning was defined as rapid intermittent interruptions of blood flow in the early phase of reperfusion, which has been found to be protective against renal ischemia-reperfusion injury (IRI) in animal models but not in clinical trials.We describe a case that the allograft renal vein was twisted because of the surgeon’s mistake, which caused the warm ischemia of allograft after reperfusion...

article

Comparative cost analysis of three different anesthesia methods in gynecological laparoscopic surgery

Xiaohui Chi, Yeling Chen, Mingfeng Liao, Fei Cao, more

Frontiers of Medicine > 2012 > 6 > 3 > 311-316

In the current study, we assessed and evaluated the costs and benefits of three popular methods of general anesthesia practiced in our department for gynecological laparoscopic surgery in recent years. Sixty adult female patients who underwent elective gynecological laparoscopic surgery under general anesthesia were randomly divided into three groups: group V, group I and group C. In group V, anesthesia...

article

Gastrointestinal damage caused by swallowing multiple magnets

Shiqi Liu, Jianhui Li, Yi Lv

Frontiers of Medicine > 2012 > 6 > 3 > 280-287

Swallowing multiple magnets is not uncommon worldwide and it frequently leads to serious consequences. However, most patients fail to receive timely and correct diagnosis and treatment. A literature search was performed to establish an algorithm for these accidents by the authors to identify relevant articles published from June 1987 to October 2010 in Google, Medline, ISI Web of Knowledge Ovid, CNKI,...

article

Estimation of the minimum effective dose of tramadol for postoperative analgesia in infants using the continual reassessment method

Yue’e Dai, Dongxu Lei, Zhenghua Huang, Yan Yin, more

Frontiers of Medicine > 2012 > 6 > 3 > 288-295

Tramadol is a potent analgesic. However, the analgesia efficacy of tramadol, particularly its minimum effective dose (MED), is not clear. The aim of this study is to find MED of tramadol for postoperative analgesia in infants. The continual reassessment method (CRM) was performed to find MED. Infants undergoing surgeries were included in the 3 phases of this series. In each phase, 24 participants...

article

Diagnostic criteria of latent autoimmune diabetes in adults (LADA): a review and reflection

Yu Liao, Yufei Xiang, Zhiguang Zhou

Frontiers of Medicine > 2012 > 6 > 3 > 243-247

Diabetes has become a major public health problem in China nowadays. There are almost 97 million diabetic patients nationwide. Latent autoimmune diabetes in adults (LADA) is a subtype of autoimmune diabetes. Although it has been reported for about 20 years, the diagnostic criteria of this disease remain controversial. The discussion mainly focused on serum autoantibodies, period of insulin need and...

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Frontiers of Medicine

Emergency strategies and trends in the management of liver trauma

Perioperative management for parturients with pulmonary hypertension: experience with 30 consecutive cases

Early and marked up-regulation of TNF-α in acute respiratory distress syndrome after cardiopulmonary bypass

EMLA® cream coated on endotracheal tube with or without epidural lidocaine reduces isoflurane requirement during general anesthesia

Orthopaedic management in the polytrauma patient

Obesity and overweight prevalence and its association with undiagnosed hypertension in Shanghai population, China: a cross-sectional population-based survey

Emergent limited perioperative transesophageal echocardiography: should new guidelines exist for limited echocardiography training for anesthesiologists?

Mechanisms and impacts of chromosomal translocations in cancers

AML1-ETO driven acute leukemia: insights into pathogenesis and potential therapeutic approaches

Potential indicators predict progress after surgical resection of gastrointestinal stromal tumors

Dual faces of SH2-containing protein-tyrosine phosphatase Shp2/PTPN11 in tumorigenesis

The second short-term warm ischemia after vascular anastomosis did not affect early renal function recovery in renal transplantation: a case report

Comparative cost analysis of three different anesthesia methods in gynecological laparoscopic surgery

Gastrointestinal damage caused by swallowing multiple magnets

Estimation of the minimum effective dose of tramadol for postoperative analgesia in infants using the continual reassessment method

Diagnostic criteria of latent autoimmune diabetes in adults (LADA): a review and reflection

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