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Human longevity is a multifactorial phenotype influenced by both genetic and environmental factors. Despite its heritability of 25–32 %, the genetic background of longevity is as yet largely unexplained. Apart from APOE status, variation in the FOXO3A gene is the only confirmed genetic contributor to survival into old age. On the other hand, FOXO3A activity is known to be downregulated in various...
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