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Although estradiol (E2) may have some beneficial effects as a treatment for menopause symptoms, E2 also has trophic effects that can increase vulnerability to some cancers, such as breast cancer. In the present study, a model to investigate the concomitant behavioral and proliferative effects of E2 was developed. First, the effects of different duration of chronic E2 exposure (2 vs 6 months), or no...
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