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A freely moving rat model was developed to study the CNS distribution of EAB 515 (S-α-amino-5-phosphonomethyl[l,1′-biphenyl]-3-propanoic acid). Microdialysis (MD) in the frontal cortex (FrC) and in the lateral ventricle (LV) of the rat brain was performed to measure the levels of EAB 515 in the cortical extracellular fluid (ECF) as well as in the cerebrospinal fluid (CSF). The femoral artery and femoral...
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