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Purpose. To compare solubility and dissolution rate of hydrocortisonein aspirated human intestinal fluids (HIFs) with simulated intestinalfluids (SIFs) and buffer. Methods. Solubility and flux from a rotating disk of hydrocortisonewere measured. The bile salt content, pH and osmotic pressure weredetermined in HIFs. Results. In fasted state the solubility of hydrocortisone was higher inHIFs...
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