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Purpose This study was conducted to investigate the interplay of secondary structure and charge of a polypeptide on its permeability through negatively charged pores of synthetic porous membranes and Caco-2 cell monolayers. Materials and Methods Poly(d-glutamic acid) [Poly(d-Glu)] was used as a model polypeptide. Transport studies were conducted at 37°C through both track-etched polycarbonate membranes...
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