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Purpose A novel naringenin-loaded nanoparticles system (NARN) was developed to resolve the restricted bioavailability of naringenin (NAR) and to enhance its hepatoprotective effects in vivo on oral administration. Materials and methods Physicochemical characterizations of NARN included assessment of particle size and morphology, powder X-ray diffraction, fourier transform infrared spectroscopy,...
Purpose To predict the absolute oral bioavailabilities (BAs) of drugs in humans without using pharmacokinetic data from intravenous administration in humans. Methods The distribution volume of the terminal phase ( $${\text{Vd}}_{\beta } $$ ) in humans was predicted by three methods using animal pharmacokinetic data. Then, total body clearance (CLtot) was calculated by multiplying the elimination...
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