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Purpose To study the effect of increasing the chain length over C-18 and varying the oxidation level in synthesized N4,N9-diacyl spermines on DNA and siRNA formulation, and then to compare their transfection efficiency in cell lines Methods The five novel very long chain N4,N9-diacyl polyamines: N4,N9-[diarachidoyl, diarachidonoyl, dieicosenoyl, dierucoyl and dinervonoyl]-1,12-diamino-4,9-diazadodecane...
Purpose To study the effect of sequentially changing the chain length, oxidation level, and charge distribution in N4,N9-diacyl and N4,N9-dialkyl spermines on siRNA formulation, and then to compare their lipoplex transfection efficiency in cell lines. Methods Eight N4,N9-diacyl polyamines: N4,N9-[didecanoyl, dilauroyl, dimyristoyl, dimyristoleoyl, dipalmitoyl, distearoyl, dioleoyl and diretinoyl]-1,12-diamino-4,9-diazadodecane...
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