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Purpose Understand the underlying mechanism governing the salt-induced precipitation of a basic (pI = 8.8) protein, Peptibody A (PbA), in acidic solutions. Methods The rate, extent, and reversibility of PbA precipitation was monitored over 4-weeks as a function of pH (3.7–5.0), salt concentration (0–400 mM), and ion identity using a series of monovalent, Hofmeister anions (F−, Cl−, Br−, I−, ClO4...
Purpose The impact of ions on protein aggregation remains poorly understood. We explored the role of ionic strength and ion identity on the temperature- and agitation-induced aggregation of antibodies. Methods Stability studies were used to determine the influence of monovalent Hofmeister anions and cations on aggregation propensity of three IgG2 mAbs. The CH2 domain melting temperature (Tm1) and...
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