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Purpose Vincristine is known to interfere with OATP-mediated uptake of other compounds, hinting that vincristine itself could be a substrate of OATP transporters. The present study therefore aimed to investigate the role of OATP transporters in the hepatocellular disposition of vincristine. Methods Vincristine uptake was studied in suspended rat and human hepatocytes as well as OATP-transfected...
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