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A series of close analogs of 4-hydroxy-6,7-dimethoxy-2-oxo-N-(pyridin-3-ylmethyl)-1,2-dihydroquinoline-3-carboxamide modified in the benzene moiety of the quinolone nucleus were synthesized to identify the structural fragments determining their analgesic effect. Results of pharmacological tests found that these chemical changes had a relatively weak influence on the analgesic activity of the tested...
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