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In the cell-mediated demyelinating diseases such as experimental allergic encephalomyelitis and multiple sclerosis, as well as their peripheral nerve counterparts, the phagocytic cells are the agent of myelin destruction. Both resident microglia and peripheral macrophages invading the nervous system have been shown to phagocytize myelin, although microglia appear to be more active, especially at early...
The ganglioside GM1 is known to play a pivotal role in neuronal survival and/or regeneration. Recently it has been shown that GM1 binds tightly with membrane-bound amyloid β protein (Aβ) and prevents its conversion from a helical to a β-sheet structure. To examine the potential physiological consequences of this binding, we studied the effect of GM1 on Aβ-stimulated release of proinflammatory cytokines,...
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