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Brain-derived neurotrophic factor (BDNF) is one of the most widely distributed protein regulators of many biological processes in the central nervous system. Like other neurotrophins, BDNF is synthesized in cells as a precursor molecule (proBDNF), which undergoes proteolytic cleavage to form the mature form, BDNF. The effectiveness of proteolysis of the proform and, thus, the proBDNF/BDNF ratio, has...
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