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We synthesized c(RGDyK)-coupled superparamagnetic iron oxide nanoparticles for specific delivery of large amount of doxorubicin to αvβ3 integrin rich tumor cells (RDSP) by using a novel triplex hands coupling reagent tris-succinimidyl aminotriacetate and evaluated their structure, drug release, target cell uptake, and cytotoxic effects. Besides the high-trapping efficient for magnetic targeting,...
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