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This study investigated the signal transduction pathway involved in the cytoprotective action of (−)schisandrin B [(−)Sch B, a stereoisomer of Sch B]. Using H9c2 cells, the authors examined the effects of (−)Sch B on MAPK and Nrf2 activation, as well as the subsequent eliciting of glutathione response and protection against apoptosis. Pharmacological tools, such as cytochrome P-450 (CYP) inhibitor,...
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