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Cyclin-dependent kinase inhibitor p21Waf1/Cip1 plays the key part in cell cycle arrest at the G1/S checkpoint in response to DNA damage, and is involved in the assembly of active cyclin–kinase complexes, in particular, cyclin D–Cdk4/6. Recent studies extended the range of known p21Waf1/Cip1 functions. In addition to the cell-cycle control, p21Waf1/Cip1 participates in important cell processes such...
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