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The majority of visual impairments are related to retinal disorders. Therefore, techniques useful for early detection of retinal anomalies are of great interest for diagnosis and treatment of related pathologies. Optical Coherence Tomography (OCT) is a non-invasive technique that is becoming increasingly important in the analysis of human retina. This technique produces sections of a three dimensional...
In this paper we propose a new procedure for classification based on a hybrid approach. The classification problem is solved by minimizing the distance between the components of each clusters and the centers of the clusters. The determination of the cluster centers is therefore a critical step in our approach and was addressed used the k-means algorithm. Once the centers of each class are determined,...
The combined analysis of tissue micro array and drug response datasets has the potential of revealing valuable knowledge about various relations among gene expressions and drug activity patterns in tumor cells. However, the amount and the complexity of biological data needs appropriate data mining models in order to extract interesting patterns and useful information. The ultimate goal of this paper...
Polymers are compounds formed by the joining of smaller, often repeating, units linked by covalent bonds. The analysis of their sequence is a fundamental issue in many areas of chemistry, medicine and biology. Nowadays, the prevalent approach to this problem consists in using a mass spectrometry analysis that gives information about the molecular weights of the polymer and of its fragments. This information...
The modern systems biology approach to the study of molecular cellular biology, consists in the development of computational tools to support the formulation of new hypotheses on the molecular mechanisms underlying the observed cell behavior. Recent biotechnologies are able to provide precise measures of gene expression time courses in response to a large variety of internal and environmental perturbations...
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