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Anticoagulation for stroke prevention in atrial fibrillation (AF) is effective. Pivotal trials RE-LY, ROCKET AF, ARISTOTLE, and ENGAGE-AF TIMI 48 tested novel agents against warfarin (W). In RE-LY, an open-label trial, dabigatran 150 mg BID (D150) was superior (35 %) and 110 mg BID (D110) was noninferior to W. D150 reduced ischemic strokes by 25 % and intracerebral bleeds by 74 %, but increased major...
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