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The aim of this study was to determine theantitumor activity of irofulven whenadministered in combination with a varietyof antimitotic agents. Irofulven incombination with either paclitaxel ordocetaxel demonstrated synergistic activityin both the in vitro and invivo studies. The majority of xenograftbearing animals that received suboptimal (< MTD) doses of irofulven and a taxanedemonstrated complete...
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