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In solid tumors, the reasons for the lack of in vitro andin vivo correlation of drugactivities are multifold and includespermeability to the tumor cells,interstitial hypertension and metabolicdegradation. So, it is important to studythe permeability and metabolic dispositionof new compounds early in discovery anddevelopment of anticancer drugs. Anexperimental anti-cancer drug, SH 30demonstrated highly...
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