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Background/purpose: 4-Ipomeanol (IPO; NSC394438), anaturally occurring furan isolated from common sweet potatoes(Ipomoea batatas) infected with the fungus Fusariumsolani was the first agent to be developed by theNationalCancer Institute based on a biochemical-biological rationaleas an anticancer agent targeted specifically against lungcancer. Prior to clinical development, IPO was shown to inducepulmonary...
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