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Background: More active agents areneeded in the treatment of metastaticnon-small cell lung cancer. Pyrazoloacridine (PZA) is a 9-methoxyacridine compound containing a reducible5-nitro substituent. Although themechanism of action of PZA is unknown, theacridine compounds are known to causecytotoxicity by interaction with DNA andRNA. Methods: Eighteen patients withmetastatic...
Background: Pyrazoloacridine (PZA) is thefirst of a new class of rationallysynthesized acridine derivatives to undergoclinical testing as an anticancer agent. We previously demonstrated cytotoxicsynergy between combinations of PZA andplatinum compounds. Subsequent studiesrevealed that PZA inhibits removal ofplatinum-DNA adducts in cultured A549cells. Based on these results, weundertook a phase I...
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