Clinical & Experimental Metastasis

article

In vivo imaging of colorectal cancer growth and metastasis by targeting MACC1 with shRNA in xenografted mice

Andreas Pichorner, Ulrike Sack, Dennis Kobelt, Inken Kelch, more

Clinical & Experimental Metastasis > 2012 > 29 > 6 > 573-583

We previously identified the gene metastasis-associated in colon cancer-1 (MACC1) and demonstrated its important role for metastasis prediction in colorectal cancer. MACC1 induces cell motility and proliferation in vitro as well as metastasis in several mouse models. Here we report non-invasive real time imaging of inhibition of colorectal tumor progression and metastasis in xenografted mice by MACC1...

article

RAF-kinase inhibitor protein (RKIP) downregulation in esophageal cancer and its metastases

Peter Birner, Bettina Jesch, Andrea Schultheis, Sebastian F. Schoppmann

Clinical & Experimental Metastasis > 2012 > 29 > 6 > 551-559

Raf kinase inhibitor protein (RKIP) is an inhibitor of Raf-mediated activation of mitogen-activated protein (MAP) kinase (MEK)-MAP kinase and is considered as an important tumor suppressor. RKIP-expression was investigated retrospectively in 321 esophageal cancers [179 adenocarcinomas (ACs), 142 squamous cell carcinomas (SCCs)]. RKIP-expression was further investigated in 41 precursor lesions consisting...

article

The histological growth pattern of colorectal cancer liver metastases has prognostic value

Gert G. Van den Eynden, Nigel C. Bird, Ali W. Majeed, Steven Van Laere, more

Clinical & Experimental Metastasis > 2012 > 29 > 6 > 541-549

Little is known about the biological characteristics that determine the prognosis of colorectal cancer (CRC) liver metastases. In previous work we reported three different histological patterns of the tumour-liver interface of CRC liver metastases, termed the pushing, replacement and desmoplastic growth pattern (GP). The purpose of this study was to confirm differences in angiogenic and hypoxic properties...

article

Inhibiting galectin-1 reduces murine lung metastasis with increased CD4⁺ and CD8⁺ T cells and reduced cancer cell adherence

Koichi Ito, Stephen J. Ralph

Clinical & Experimental Metastasis > 2012 > 29 > 6 > 561-572

Galectin-1 is a β-galactoside-binding protein overexpressed by cancer cells. The primary roles of galectin-1 in cancer progression and metastasis are attributed to suppression of T cell immune responses, promotion of tumor angiogenesis and increased tumor cell adhesion and invasion. Using pulmonary metastasis models of murine breast (4T1) and colon (CT26) cancer, we demonstrate that targeting galectin-1...

article

Kurt Hellmann D.M., D.Phil. Oxon. A happy 90th birthday!

Suzanne A. Eccles, Rudolf K. Steiner

Clinical & Experimental Metastasis > 2012 > 29 > 6 > 523-526

An erratum to this article can be found at http://dx.doi.org/10.1007/s10585-012-9513-1 .

article

Targeting monocyte chemotactic protein-1 synthesis with bindarit induces tumor regression in prostate and breast cancer animal models

Massimo Zollo, Valeria Dato, Daniela Spano, Daniela Martino, more

Clinical & Experimental Metastasis > 2012 > 29 > 6 > 585-601

Prostate and breast cancer are major causes of death worldwide, mainly due to patient relapse upon disease recurrence through formation of metastases. Chemokines are small proteins with crucial roles in the immune system, and their regulation is finely tuned in early inflammatory responses. They are key molecules during inflammatory processes, and many studies are focusing on their regulatory functions...

article

Profiling immunohistochemical expression of NOTCH1–3, JAGGED1, cMET, and phospho-MAPK in 100 carcinomas of unknown primary

Dimitrios Krikelis, George Pentheroudakis, Anna Goussia, Vassiliki Siozopoulou, more

Clinical & Experimental Metastasis > 2012 > 29 > 6 > 603-614

Cancer of unknown primary (CUP) is a heterogeneous entity, managed on the basis of “one size fits all” therapeutic concepts; insights into the molecular biology of CUP are urgently needed. We retrospectively examined the immunohistochemical (IHC) expression of Notch1, 2, 3, Jagged1, cMET, and pMAPK biomolecules in 100 CUP tumors using tissue microarrays, aiming to study their correlation to clinicopathologic...

article

CCL27–CCR10 and CXCL12–CXCR4 chemokine ligand-receptor mRNA expression ratio: new predictive factors of tumor progression in cutaneous malignant melanoma

Carlos Monteagudo, David Ramos, Ana Pellín-Carcelén, Rosario Gil, more

Clinical & Experimental Metastasis > 2012 > 29 > 6 > 625-637

CXCR4, CCR7 and CCR10 chemokine receptors are known to be involved in melanoma metastasis. Our goal was to compare the relative intratumoral mRNA expression of these receptors with that of their corresponding chemokine ligands, CXCL12, CCL19, CCL21, and CCL27 across the full spectrum of human melanoma progression: thin and thick primary melanomas, as well as “in transit”, lymph node, and distant metastases...

article

Ezrin and BCAR1/p130Cas mediate breast cancer growth as 3-D spheroids

Sophya Konstantinovsky, Ben Davidson, Reuven Reich

Clinical & Experimental Metastasis > 2012 > 29 > 6 > 527-540

CAS proteins and Ezrin, Radixin, Moesin (ERM) family members act as intracellular scaffolds and are involved in interactions with the cytoskeleton, respectively. Both protein families have previously been associated with metastasis and poor prognosis in cancer. Our group recently reported on the overexpression of EZR/VIL2 and BCAR1 and their protein products in breast carcinoma effusions compared...

article

Phosphorylation of signal transducer and activator of transcription 3 (STAT3) correlates with Her-2 status, carbonic anhydrase 9 expression and prognosis in esophageal cancer

Sebastian F. Schoppmann, Bettina Jesch, Julia Friedrich, Gerd Jomrich, more

Clinical & Experimental Metastasis > 2012 > 29 > 6 > 615-624

The signal-transcriptional factor signal transducer and activator of transcription (STAT3) is overexpressed in various tumor entities and promotes tumor progression and metastasis. The tyrosine-kinase receptor Her-2 was shown to activate STAT3-expression and is overexpressed in a subtype of esophageal cancer (EC). STAT3 also regulates carbonic anhydrase IX (CAIX) expression in vivo, promoting IL-6-dependent...

INFONA - science communication portal

Clinical & Experimental Metastasis

In vivo imaging of colorectal cancer growth and metastasis by targeting MACC1 with shRNA in xenografted mice

RAF-kinase inhibitor protein (RKIP) downregulation in esophageal cancer and its metastases

The histological growth pattern of colorectal cancer liver metastases has prognostic value

Inhibiting galectin-1 reduces murine lung metastasis with increased CD4⁺ and CD8⁺ T cells and reduced cancer cell adherence

Kurt Hellmann D.M., D.Phil. Oxon. A happy 90th birthday!

Targeting monocyte chemotactic protein-1 synthesis with bindarit induces tumor regression in prostate and breast cancer animal models

Profiling immunohistochemical expression of NOTCH1–3, JAGGED1, cMET, and phospho-MAPK in 100 carcinomas of unknown primary

CCL27–CCR10 and CXCL12–CXCR4 chemokine ligand-receptor mRNA expression ratio: new predictive factors of tumor progression in cutaneous malignant melanoma

Ezrin and BCAR1/p130Cas mediate breast cancer growth as 3-D spheroids

Phosphorylation of signal transducer and activator of transcription 3 (STAT3) correlates with Her-2 status, carbonic anhydrase 9 expression and prognosis in esophageal cancer

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