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Many studies have shown that the functional architecture of eukaryotic genomes displays striking similarities in evolutionarily distant organisms. For example, late-replicating and transcriptionally inactive chromatin is associated with the nuclear periphery in organisms as different as budding yeast and man. These findings suggest that eukaryotic genomes are organized in cell nuclei according to...
DNA replication occupies a central position in the cell cycle and, therefore, in the development and life of multicellular organisms. During the last 10 years, our comprehension of this important process has considerably improved. Although the mechanisms that coordinate DNA replication with the other moments of the cell cycle are not yet fully understood, it is known that they mainly operate through...
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