Breast Cancer Research and Treatment

Items from 1 to 18 out of 18 results

article

Simultaneous two-color spectral fluorescence lymphangiography with near infrared quantum dots to map two lymphatic flows from the breast and the upper extremity

Yukihiro Hama, Yoshinori Koyama, Yasuteru Urano, Peter L. Choyke, more

Breast Cancer Research and Treatment > 2007 > 103 > 1 > 23-28

Due to their small size and poor access, the lymphatic function has been difficult to study in vivo. Especially difficult is the mapping of lymphatic drainage from two basins into the same node. Quantum dots can be used to perform multicolor images with high fluorescent intensity and are of a nano-size size suitable for lymphatic imaging via direct interstitial injection. Here we show simultaneous...

article

Differentially expressed genes between primary cancer and paired lymph node metastases predict clinical outcome of node-positive breast cancer patients

Yumei Feng, Baocun Sun, Xiaoqing Li, Liang Zhang, more

Breast Cancer Research and Treatment > 2007 > 103 > 1 > 125-127

The online version of the original article can be found at http://doi.org/10.1007/s10549-006-9385-7

article

Screening for large rearrangements of the BRCA2 gene in Spanish families with breast/ovarian cancer

Sara Gutiérrez-Enríquez, Miguel La Hoya, Cristina Martínez-Bouzas, Ana Sanchez Abajo, more

Breast Cancer Research and Treatment > 2007 > 103 > 1 > 103-107

Germ-line mutations in BRCA1 and BRCA2 are responsible for about 30–60% of the hereditary breast and ovarian cancer (HBOC). A large number of point mutations have been described in both genes. However, large deletions and duplications that disrupt one or more exons are overlooked by point mutation detection approaches. Over the past years several rearrangements have been identified in BRCA1, while...

article

Transfer of siRNA against XIAP induces apoptosis and reduces tumor cells growth potential in human breast cancer in vitro and in vivo

Yingchao Zhang, Yu Wang, Wenxin Gao, Ruhui Zhang, more

Breast Cancer Research and Treatment > 2007 > 103 > 1 > 129-129

The online version of the original article can be found at http://dx.doi.org/10.1007/s10549-005-9080-0

article

CHEK2 1100delC is present in familial breast cancer cases of the Basque Country

Cristina Martínez-Bouzas, Elena Beristain, Isabel Guerra, Javier Gorostiaga, more

Breast Cancer Research and Treatment > 2007 > 103 > 1 > 111-113

article

Characterization of molecular and structural determinants of selective estrogen receptor downregulators

Meiyun Fan, Emily L. Rickert, Lei Chen, Syed A. Aftab, more

Breast Cancer Research and Treatment > 2007 > 103 > 1 > 37-44

Antiestrogens used for breast cancer therapy can be categorized into two classes that differ in their effect on estrogen receptor (ER) alpha stability. The selective estrogen receptor modulators (SERMs) stabilize ER alpha and the selective estrogen receptor downregulators (SERDs) cause a decrease in cellular ER alpha levels. A clinically relevant antiestrogen, GW7604, appears to work through a SERD-like...

article

Methyl group metabolism gene polymorphisms as modifier of breast cancer risk in Italian BRCA1/2 carriers

C. Pepe, L. Guidugli, E. Sensi, P. Aretini, more

Breast Cancer Research and Treatment > 2007 > 103 > 1 > 29-36

BRCA1 and 2 are major cancer susceptibility genes but their penetrance is highly variable. The folate metabolism plays an important role in DNA methylation and its alterated metabolism is associated with cancer risk. The role of allele variants 677T and 1298C (MTHFR gene) and 2756G (MS gene) has been investigated as potentially modifying factors of BRCA gene penetrance, evaluated as age at first diagnosis...

article

Genetic polymorphism of XRCC3 Thr²⁴¹Met and breast cancer risk: case-control study in Korean women and meta-analysis of 12 studies

Sang-Ah Lee, Kyoung-Mu Lee, Sue Kyung Park, Ji-Yeob Choi, more

Breast Cancer Research and Treatment > 2007 > 103 > 1 > 71-76

To evaluate the relationship of genetic polymorphism in XRCC3 Thr²⁴¹Met and the risk of breast cancer, a hospital-based case-control study was conducted in Korea. Histologically confirmed breast cancer cases (n = 574) and controls (n = 502) with no present or previous history of cancer were recruited from several teaching hospitals in Seoul during 1995–2001. Information on demographic characteristics...

article

29th Annual San Antonio Breast Cancer Symposium 2006

Breast Cancer Research and Treatment > 2007 > 103 > 1 > 115-124

article

Is survivin expression nevertheless related to disease outcome in breast cancer?

Paul N. Span, Vivianne C. G. Tjan-Heijnen, Fred C. G. J. Sweep

Breast Cancer Research and Treatment > 2007 > 103 > 1 > 109-109

article

Male breast cancer: a review of clinical management

A. Agrawal, A. A. Ayantunde, R. Rampaul, J. F. R. Robertson

Breast Cancer Research and Treatment > 2007 > 103 > 1 > 11-21

Aims Male breast cancer incidence is 1% of all breast cancers and is increasing. We aim to present an overview of male breast cancer with particular emphasis on clinical management. Methods Studies were identified by an online search of literature in the MEDLINE database till June 2006 followed by an extensive review of bibliographies. Results Increased risk factors include genetic predisposition...

article

Physician and patient characteristics associated with outpatient breast cancer screening recommendations in the United States: analysis of the National Ambulatory Medical Care Survey Data 1996–2004

Monali Bhosle, Stephen Samuel, Venkatanaras Vosuri, Electra Paskett, more

Breast Cancer Research and Treatment > 2007 > 103 > 1 > 53-59

Background The primary goal of breast cancer screening tests is to find cancer at an early stage before a person has any symptoms. Evidence suggests that screening examinations such as mammography and clinical breast examinations (CBE) are effective in early detection of breast cancer. Physician recommendation is an important reason many women undergo screening. This study examined the physician and...

article

Breast-conserving surgery for T3/T4 breast cancer: an analysis of 196 patients

Florian Fitzal, Otto Riedl, Lisa Wutzl, Wolfgang Draxler, more

Breast Cancer Research and Treatment > 2007 > 103 > 1 > 45-52

Introduction Breast conservation therapy (BCT) increases quality of life and self-esteem of breast cancer patients. In special cancer centers up to 90% of patients are treated with BCT. T3/T4 breast cancer is one of the few contraindications for BCT. However, retrospective data suggest that BCT may be eligible in selected cases of T3/T4 breast cancer. Method We analyzed retrospectively 196 breast...

article

Promoter polymorphisms in matrix metalloproteinases and their inhibitors: few associations with breast cancer susceptibility and progression

Haixin Lei, Kari Hemminki, Andrea Altieri, Robert Johansson, more

Breast Cancer Research and Treatment > 2007 > 103 > 1 > 61-69

The importance of matrix metalloproteinases and their inhibitors in tumor progression is well documented. We wanted to investigate if single nucleotide polymorphisms (SNPs) in the promoter regions of these genes are associated with susceptibility to or progression of breast cancer. In this, so far largest case–control study, we genotyped eight SNPs in the MMP1, MMP2, MMP3, MMP9, MMP13, RECK and TIMP3...

article

Magnetic resonance imaging of breast lesions—a pathologic correlation

Gary M. K. Tse, Benjaporn Chaiwun, Ka-Tak Wong, David K. Yeung, more

Breast Cancer Research and Treatment > 2007 > 103 > 1 > 1-10

Magnetic resonance imaging of the breast is useful in assessing breast lesions. An understanding of the pathologic characteristics of the tumors may help to understand these magnetic resonance imaging observations. Large lesional size (>10 mm), ill-defined margin, and irregular outlines are associated with malignancy. These correlate with the pathological features of breast tumor, characterized...

article

The effects of radiotherapy for the treatment of contralateral breast cancer

Mario Schootman, Donna B. Jeffe, William E. Gillanders, Yan Yan, more

Breast Cancer Research and Treatment > 2007 > 103 > 1 > 77-83

Radiotherapy following breast-conserving surgery for the treatment of first primary breast cancer is the standard of care and is widely used despite its small survival benefit. The effects of radiotherapy in metachronous contralateral breast cancer are unknown. We examined the use of radiotherapy and its effect on cause-specific and all-cause mortality among women with metachronous contralateral breast...

article

Accuracy of fine needle aspiration cytology (FNAC) of axillary lymph nodes as a triage test in breast cancer staging

Stefano Ciatto, Beniamino Brancato, Gabriella Risso, Daniela Ambrogetti, more

Breast Cancer Research and Treatment > 2007 > 103 > 1 > 85-91

Introduction Axillary node fine needle aspiration cytology (FNAC) has the potential to triage women with operable breast cancer to initial nodal surgical procedure. Because of variability in the reported accuracy of this test its role and clinical utility in pre-operative staging remains controversial. Methods We retrospectively evaluated the accuracy of ultrasound-guided axillary FNAC in all consecutive...

article

Association between reproductive factors and breast cancer survival in younger women

Katrina F. Trivers, Marilie D. Gammon, Page E. Abrahamson, Mary Jo Lund, more

Breast Cancer Research and Treatment > 2007 > 103 > 1 > 93-102

This analysis investigated whether reproductive factors such as age at menarche, parity, and timing and outcomes of pregnancies were associated with survival among women with breast cancer younger than 55 years. Female residents of Atlanta, Georgia, and central New Jersey who were diagnosed with a primary, incident invasive breast cancer between 1990 and 1992 and enrolled in a population-based study...

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2007

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Keywords

BREAST CANCER (5)
BREAST (2)
BRCA1 (1)
BRCA2 (1)
AETIOLOGY (1)
ANTIESTROGEN (1)
AXILLARY STAGING (1)
BRCA1/2 (1)
BREAST CANCER RISK (1)
BREAST CANCER SCREENING (1)
BREAST CANCER SUSCEPTIBILITY (1)
BREAST NEOPLASMS (1)
BREAST ULTRASOUND (1)
CANCER (1)
CANCER PROGNOSIS (1)
CANCER RISK (1)
CASE-CONTROL STUDY IN KOREAN WOMEN (1)
CASE–CONTROL STUDY (1)
CLINICAL BREAST EXAM (1)
CLINICAL STUDY (1)
CONSERVATION (1)
DNA METHYLATION (1)
ESTROGEN RECEPTOR DEGRADATION (1)
GENE PENETRANCE MODIFIERS (1)
GENOMIC REARRANGEMENTS (1)
GW5638 (1)
GW7604 (1)
HEREDITARY BREAST AND/OR OVARIAN CANCER (1)
HEREDITARY BREAST CANCER (1)
IMAGING (1)
LOCALLY ADVANCED (1)
LYMPH NODE (1)
LYMPH NODES (1)
LYMPHATIC DRAINAGE (1)
LYMPHEDEMA (1)
MAGNETIC RESONANCE IMAGING (1)
MALE (1)
MAMMOGRAPHY (1)
META-ANALYSIS (1)
METACHRONOUS (1)
MMP (1)
MORTALITY (1)
NANOTECHNOLOGY (1)
NEAR INFRARED (1)
NEEDLE BIOPSY (1)
NEOPLASM (1)
ONCOLOGY (1)
OUTPATIENT CARE (1)
PATHOLOGY (1)
POLYMORPHISM (1)
QUANTUM DOTS (1)
RADIOTHERAPY (1)
RECK (1)
RECURRENCE (1)
REPRODUCTIVE FACTORS (1)
REPRODUCTIVE HISTORY (1)
RETROSPECTIVE STUDY (1)
SECOND PRIMARY NEOPLASM (1)
SELECTIVE ESTROGEN RECEPTOR DOWNREGULATOR (1)
SELECTIVE ESTROGEN RECEPTOR MODULATOR (1)
SIZE (1)
SPECTRAL FLUORESCENCE IMAGING (1)
SURGERY (1)
SURVIVAL (1)
TAMOXIFEN (1)
THE GENETIC POLYMORPHISM OF XRCC3 THR241MET (1)
TIMP (1)
TREATMENT (1)
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