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A Simulated Moving Bed (SMB) setup, including 8 new β-cyclodextrin columns, was used to achieve the enantioseparation of fluoxetine. The effects of feed concentration and feed flowrate on the operation performance parameters: purity, enrichment, recovery and productivity were studied. A simulation approach was applied to simulate the operation and performance of the simulated counter-current system...
This work proposes a methodology for comparing different multi-column chromatographic processes (SMB, ISMB, SSMB) for purifying monosaccharides. The first step of the methodology consists in determining the flow rates associated with the different processes assuming that the columns are infinitely efficient. This allows deriving “idealized” operating conditions. In a second step, using the “idealized”...
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